藥物交互作用
Dofetilide + Dolutegravir
嚴重程度: 禁忌併用
Dofetilide and Dolutegravir: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Dolutegravir increases dofetilide plasma concentrations, which can prolong the QT interval and cause torsades de pointes. Dofetilide has a narrow therapeutic index, so even modest increases are dangerous.
用白話說明這項交互作用的意義
Dofetilide and Dolutegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Dolutegravir belongs to Anti Virals.
為什麼會發生
Dolutegravir inhibits renal OCT2 and MATE1, reducing the tubular secretion of dofetilide.
處置方式
Do not coadminister; select an alternative antiarrhythmic or a different antiretroviral.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dolutegravir 的其他交互作用
Dofetilide 的其他交互作用
常見問題
Can I take Dofetilide with Dolutegravir?
MediHelp rates the interaction as contraindicated. Dofetilide and Dolutegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dolutegravir increases dofetilide plasma concentrations, which can prolong the QT interval and cause torsades de pointes. Dofetilide has a narrow therapeutic index, so even modest increases are dangerous.
How serious is the interaction between Dofetilide and Dolutegravir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select an alternative antiarrhythmic or a different antiretroviral.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Aluminum hydroxide, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Dolutegravir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
