藥物交互作用
Enzalutamide + Mavacamten
嚴重程度: 禁忌併用
Enzalutamide and Mavacamten: contraindicated interaction.
最後更新
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摘要
Mavacamten is cleared by CYP2C19 and CYP3A4, and enzalutamide induces both, lowering exposure and reducing therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.
用白話說明這項交互作用的意義
Enzalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Enzalutamide belongs to Endocrine; Mavacamten belongs to Cardiovascular.
為什麼會發生
Induction of CYP2C19 and CYP3A4 by enzalutamide increases mavacamten clearance.
處置方式
Avoid the combination; if enzalutamide is started or stopped in a mavacamten patient, check LVEF and gradient by echocardiography and adjust the dose.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Enzalutamide 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Enzalutamide with Mavacamten?
MediHelp rates the interaction as contraindicated. Enzalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared by CYP2C19 and CYP3A4, and enzalutamide induces both, lowering exposure and reducing therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.
How serious is the interaction between Enzalutamide and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if enzalutamide is started or stopped in a mavacamten patient, check LVEF and gradient by echocardiography and adjust the dose.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
