藥物交互作用
Efavirenz + Mavacamten
嚴重程度: 禁忌併用
Efavirenz and Mavacamten: contraindicated interaction.
最後更新
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摘要
Efavirenz affects CYP2C19 and CYP3A4, both of which metabolise mavacamten, so exposure may become unpredictable. Increased exposure can cause systolic dysfunction and heart failure, while reduced exposure impairs efficacy.
用白話說明這項交互作用的意義
Efavirenz and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Mavacamten belongs to Cardiovascular.
為什麼會發生
Efavirenz modulation of CYP3A4 and CYP2C19 metabolism of mavacamten.
處置方式
Avoid the combination and use an alternative antiretroviral. If an interacting drug is started or stopped, monitor LVEF closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Efavirenz 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Efavirenz with Mavacamten?
MediHelp rates the interaction as contraindicated. Efavirenz and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz affects CYP2C19 and CYP3A4, both of which metabolise mavacamten, so exposure may become unpredictable. Increased exposure can cause systolic dysfunction and heart failure, while reduced exposure impairs efficacy.
How serious is the interaction between Efavirenz and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiretroviral. If an interacting drug is started or stopped, monitor LVEF closely.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
