藥物交互作用
Apalutamide + Mavacamten
嚴重程度: 禁忌併用
Apalutamide and Mavacamten: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Apalutamide can substantially reduce mavacamten exposure, which may result in loss of therapeutic effect on left ventricular outflow obstruction. Stopping the inducer later can also cause exposure to rise unexpectedly.
用白話說明這項交互作用的意義
Apalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Mavacamten belongs to Cardiovascular.
為什麼會發生
Apalutamide induces CYP2C19 and CYP3A4, the main enzymes that metabolize mavacamten.
處置方式
Avoid the combination; use an alternative to apalutamide. Monitor echocardiographic response if the inducer is started or stopped.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Apalutamide 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Apalutamide with Mavacamten?
MediHelp rates the interaction as contraindicated. Apalutamide and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide can substantially reduce mavacamten exposure, which may result in loss of therapeutic effect on left ventricular outflow obstruction. Stopping the inducer later can also cause exposure to rise unexpectedly.
How serious is the interaction between Apalutamide and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative to apalutamide. Monitor echocardiographic response if the inducer is started or stopped.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
