藥物交互作用
Clarithromycin + Mavacamten
嚴重程度: 禁忌併用
Clarithromycin and Mavacamten: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Clarithromycin may substantially increase mavacamten exposure, which can excessively reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction. Strong CYP3A4 inhibitors are contraindicated in the labeling.
用白話說明這項交互作用的意義
Clarithromycin and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Mavacamten belongs to Cardiovascular.
為什麼會發生
Clarithromycin inhibits CYP3A4 (and CYP2C19 contributions) and thereby reduces mavacamten clearance.
處置方式
Do not coadminister; use an alternative antibiotic such as azithromycin and monitor LVEF if exposure occurs.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clarithromycin 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Clarithromycin with Mavacamten?
MediHelp rates the interaction as contraindicated. Clarithromycin and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin may substantially increase mavacamten exposure, which can excessively reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction. Strong CYP3A4 inhibitors are contraindicated in the labeling.
How serious is the interaction between Clarithromycin and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic such as azithromycin and monitor LVEF if exposure occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
