藥物交互作用
Amphotericin b + Fludrocortisone
嚴重程度: 嚴重
Amphotericin b and Fludrocortisone: major interaction.
最後更新
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摘要
Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and amphotericin B independently causes potassium wasting. The combination can lead to significant and sometimes severe hypokalemia.
用白話說明這項交互作用的意義
Amphotericin b and Fludrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Fludrocortisone belongs to Endocrine.
為什麼會發生
Additive renal potassium loss from mineralocorticoid receptor stimulation and amphotericin B-induced distal tubular leak.
處置方式
Monitor potassium and magnesium frequently and give replacement early. Reassess the need for fludrocortisone dose or concurrent use if hypokalemia persists.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amphotericin b 的其他交互作用
Fludrocortisone 的其他交互作用
- Fludrocortisone + Mifepristone 禁忌併用
- Aldesleukin + Fludrocortisone 嚴重
- Bcg vaccine live + Fludrocortisone 嚴重
- Fludrocortisone + Influenza virus vaccine quadrivalent intranasal 嚴重
- Fludrocortisone + Measles mumps and rubella vaccine live 嚴重
- Fludrocortisone + Measles mumps rubella and varicella vaccine live 嚴重
常見問題
Can I take Amphotericin b with Fludrocortisone?
MediHelp rates the interaction as major. Amphotericin b and Fludrocortisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and amphotericin B independently causes potassium wasting. The combination can lead to significant and sometimes severe hypokalemia.
How serious is the interaction between Amphotericin b and Fludrocortisone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium frequently and give replacement early. Reassess the need for fludrocortisone dose or concurrent use if hypokalemia persists.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
