藥物交互作用
Fluoxetine + Selegiline
嚴重程度: 禁忌併用
Fluoxetine and Selegiline: contraindicated interaction.
最後更新
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摘要
Selegiline inhibits MAO-B and loses selectivity at higher doses, and fluoxetine inhibits serotonin reuptake. Serotonin syndrome has been reported, and fluoxetine also inhibits CYP2D6, raising selegiline exposure.
用白話說明這項交互作用的意義
Fluoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
為什麼會發生
MAO inhibition plus serotonin reuptake inhibition; CYP inhibition raises selegiline levels
處置方式
Do not use together; allow at least 5 weeks after stopping fluoxetine before starting selegiline, and 14 days after stopping selegiline before starting fluoxetine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluoxetine 的其他交互作用
Selegiline 的其他交互作用
常見問題
Can I take Fluoxetine with Selegiline?
MediHelp rates the interaction as contraindicated. Fluoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and loses selectivity at higher doses, and fluoxetine inhibits serotonin reuptake. Serotonin syndrome has been reported, and fluoxetine also inhibits CYP2D6, raising selegiline exposure.
How serious is the interaction between Fluoxetine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow at least 5 weeks after stopping fluoxetine before starting selegiline, and 14 days after stopping selegiline before starting fluoxetine.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
