藥物交互作用
Fluoxetine + Mavacamten
嚴重程度: 禁忌併用
Fluoxetine and Mavacamten: contraindicated interaction.
最後更新
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摘要
Mavacamten is cleared largely by CYP2C19 with a contribution from CYP3A4, and fluoxetine inhibits both CYP2C19 and CYP2D6. Higher mavacamten exposure can reduce ejection fraction and precipitate heart failure from systolic dysfunction.
用白話說明這項交互作用的意義
Fluoxetine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
為什麼會發生
Fluoxetine inhibition of CYP2C19 (and CYP3A4 to a lesser degree) decreases mavacamten clearance.
處置方式
Avoid the combination; if an antidepressant is needed, choose one without significant CYP2C19 inhibition. If fluoxetine is started or stopped, monitor LVEF and mavacamten dosing closely per labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluoxetine 的其他交互作用
Mavacamten 的其他交互作用
常見問題
Can I take Fluoxetine with Mavacamten?
MediHelp rates the interaction as contraindicated. Fluoxetine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared largely by CYP2C19 with a contribution from CYP3A4, and fluoxetine inhibits both CYP2C19 and CYP2D6. Higher mavacamten exposure can reduce ejection fraction and precipitate heart failure from systolic dysfunction.
How serious is the interaction between Fluoxetine and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if an antidepressant is needed, choose one without significant CYP2C19 inhibition. If fluoxetine is started or stopped, monitor LVEF and mavacamten dosing closely per labeling.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Fluoxetine page.
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