藥物交互作用
Fluvoxamine + Mexiletine
嚴重程度: 嚴重
Fluvoxamine and Mexiletine: major interaction.
最後更新
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摘要
Mexiletine is metabolized partly by CYP1A2 and CYP2D6, and fluvoxamine strongly inhibits CYP1A2, so mexiletine exposure can increase. This raises the risk of neurologic and gastrointestinal adverse effects and proarrhythmia.
用白話說明這項交互作用的意義
Fluvoxamine and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Mexiletine belongs to Cardiovascular.
為什麼會發生
Fluvoxamine inhibits CYP1A2 (and to a lesser extent other enzymes), reducing mexiletine clearance.
處置方式
Reduce the mexiletine dose and monitor for toxicity and ECG changes, or choose an alternative antidepressant that does not inhibit CYP1A2.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mexiletine 的其他交互作用
Fluvoxamine 的其他交互作用
常見問題
Can I take Fluvoxamine with Mexiletine?
MediHelp rates the interaction as major. Fluvoxamine and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mexiletine is metabolized partly by CYP1A2 and CYP2D6, and fluvoxamine strongly inhibits CYP1A2, so mexiletine exposure can increase. This raises the risk of neurologic and gastrointestinal adverse effects and proarrhythmia.
How serious is the interaction between Fluvoxamine and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the mexiletine dose and monitor for toxicity and ECG changes, or choose an alternative antidepressant that does not inhibit CYP1A2.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
