藥物交互作用
Gemfibrozil + Iptacopan
嚴重程度: 中度
Gemfibrozil and Iptacopan: moderate interaction.
最後更新
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摘要
Iptacopan is partly metabolized by CYP2C8, and gemfibrozil is a strong CYP2C8 inhibitor. The interaction may increase iptacopan exposure, although the clinical consequence is uncertain.
用白話說明這項交互作用的意義
Gemfibrozil and Iptacopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Iptacopan belongs to Miscellaneous.
為什麼會發生
Gemfibrozil and its glucuronide inhibit CYP2C8, decreasing iptacopan metabolism.
處置方式
Monitor for iptacopan adverse effects such as headache and infection, including encapsulated bacterial infection. Consider an alternative lipid-lowering drug if exposure concerns arise.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Gemfibrozil 的其他交互作用
Iptacopan 的其他交互作用
常見問題
Can I take Gemfibrozil with Iptacopan?
MediHelp rates the interaction as moderate. Gemfibrozil and Iptacopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iptacopan is partly metabolized by CYP2C8, and gemfibrozil is a strong CYP2C8 inhibitor. The interaction may increase iptacopan exposure, although the clinical consequence is uncertain.
How serious is the interaction between Gemfibrozil and Iptacopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for iptacopan adverse effects such as headache and infection, including encapsulated bacterial infection. Consider an alternative lipid-lowering drug if exposure concerns arise.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
