藥物交互作用
Glycerol phenylbutyrate + Methylprednisolone
嚴重程度: 中度
Glycerol phenylbutyrate and Methylprednisolone: moderate interaction.
最後更新
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摘要
Corticosteroids promote protein catabolism and can raise plasma ammonia. This may counteract the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders and risk hyperammonemia.
用白話說明這項交互作用的意義
Glycerol phenylbutyrate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Methylprednisolone belongs to Endocrine.
為什麼會發生
Glucocorticoid-induced protein catabolism increases nitrogen load and ammonia production, opposing the nitrogen-scavenging effect.
處置方式
Monitor plasma ammonia closely when starting or changing corticosteroid therapy and adjust glycerol phenylbutyrate dosing as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Methylprednisolone 的其他交互作用
- Bcg vaccine live + Methylprednisolone 禁忌併用
- Measles mumps and rubella vaccine live + Methylprednisolone 禁忌併用
- Measles mumps rubella and varicella vaccine live + Methylprednisolone 禁忌併用
- Measles vaccine + Methylprednisolone 禁忌併用
- Methylprednisolone + Mifepristone 禁忌併用
- Methylprednisolone + Rubella vaccine 禁忌併用
Glycerol phenylbutyrate 的其他交互作用
常見問題
Can I take Glycerol phenylbutyrate with Methylprednisolone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and can raise plasma ammonia. This may counteract the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders and risk hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting or changing corticosteroid therapy and adjust glycerol phenylbutyrate dosing as needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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