藥物交互作用
Haloperidol + Pimozide
嚴重程度: 禁忌併用
Haloperidol and Pimozide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Haloperidol blocks hERG channels and carries a recognised dose-related QTc and torsades de pointes risk, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
用白話說明這項交互作用的意義
Haloperidol and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
為什麼會發生
Additive blockade of cardiac repolarising potassium currents (hERG)
處置方式
Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Haloperidol 的其他交互作用
Pimozide 的其他交互作用
常見問題
Can I take Haloperidol with Pimozide?
MediHelp rates the interaction as contraindicated. Haloperidol and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Haloperidol blocks hERG channels and carries a recognised dose-related QTc and torsades de pointes risk, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Haloperidol and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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