藥物交互作用
Ibutilide + Maprotiline
嚴重程度: 禁忌併用
Ibutilide and Maprotiline: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ibutilide markedly prolongs repolarisation and carries a significant risk of torsades de pointes. Adding maprotiline, which also lengthens the QT interval, further increases the likelihood of life-threatening ventricular arrhythmia.
用白話說明這項交互作用的意義
Ibutilide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
為什麼會發生
Additive pharmacodynamic prolongation of the QT interval.
處置方式
Do not give ibutilide to patients taking maprotiline; consider an alternative cardioversion strategy such as electrical cardioversion. Review the need for maprotiline if rhythm control with QT-prolonging agents is planned.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Maprotiline 的其他交互作用
Ibutilide 的其他交互作用
常見問題
Can I take Ibutilide with Maprotiline?
MediHelp rates the interaction as contraindicated. Ibutilide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs repolarisation and carries a significant risk of torsades de pointes. Adding maprotiline, which also lengthens the QT interval, further increases the likelihood of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Maprotiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ibutilide to patients taking maprotiline; consider an alternative cardioversion strategy such as electrical cardioversion. Review the need for maprotiline if rhythm control with QT-prolonging agents is planned.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
