藥物交互作用
Ibutilide + Methadone
嚴重程度: 禁忌併用
Ibutilide and Methadone: contraindicated interaction.
最後更新
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摘要
Ibutilide markedly prolongs repolarization and causes torsades de pointes; adding methadone, which also prolongs QT, further raises this risk. The arrhythmia can be rapid and fatal.
用白話說明這項交互作用的意義
Ibutilide and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Methadone belongs to Musculoskeletal.
為什麼會發生
Additive pharmacodynamic QT prolongation via potassium channel (hERG) blockade.
處置方式
Do not give together; use an alternative rhythm-control strategy such as electrical cardioversion if appropriate. If methadone cannot be withheld, ensure continuous ECG monitoring and correct electrolytes, accepting substantial risk.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Methadone 的其他交互作用
Ibutilide 的其他交互作用
常見問題
Can I take Ibutilide with Methadone?
MediHelp rates the interaction as contraindicated. Ibutilide and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide markedly prolongs repolarization and causes torsades de pointes; adding methadone, which also prolongs QT, further raises this risk. The arrhythmia can be rapid and fatal.
How serious is the interaction between Ibutilide and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together; use an alternative rhythm-control strategy such as electrical cardioversion if appropriate. If methadone cannot be withheld, ensure continuous ECG monitoring and correct electrolytes, accepting substantial risk.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
