藥物交互作用
Isocarboxazid + Methadone
嚴重程度: 禁忌併用
Isocarboxazid and Methadone: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining methadone with a nonselective MAO inhibitor risks serotonin toxicity, hypotension, hyperthermia, marked sedation and respiratory depression. Methadone's labeling warns against use with MAOIs or within 14 days of stopping one.
用白話說明這項交互作用的意義
Isocarboxazid and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
為什麼會發生
MAO inhibition combined with methadone's serotonergic activity may precipitate serotonin syndrome, plus additive CNS depression.
處置方式
Do not use together or within 14 days of stopping the MAOI. Use a non-serotonergic analgesic or opioid-treatment alternative.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Methadone 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Isocarboxazid with Methadone?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining methadone with a nonselective MAO inhibitor risks serotonin toxicity, hypotension, hyperthermia, marked sedation and respiratory depression. Methadone's labeling warns against use with MAOIs or within 14 days of stopping one.
How serious is the interaction between Isocarboxazid and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping the MAOI. Use a non-serotonergic analgesic or opioid-treatment alternative.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
