藥物交互作用
Levoketoconazole + Methadone
嚴重程度: 禁忌併用
Levoketoconazole and Methadone: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
用白話說明這項交互作用的意義
Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Methadone belongs to Musculoskeletal.
為什麼會發生
CYP3A4 inhibition raises methadone exposure, with additive QT prolongation.
處置方式
Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Methadone 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Levoketoconazole with Methadone?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
How serious is the interaction between Levoketoconazole and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
