藥物交互作用
Ibutilide + Nilotinib
嚴重程度: 禁忌併用
Ibutilide and Nilotinib: contraindicated interaction.
最後更新
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摘要
Ibutilide strongly prolongs repolarization and has a high torsades risk. Adding nilotinib, which also prolongs QT, further increases the likelihood of life-threatening ventricular arrhythmia.
用白話說明這項交互作用的意義
Ibutilide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Nilotinib belongs to Oncology.
為什麼會發生
Additive QT prolongation via potassium channel blockade.
處置方式
Do not use together. Consider another rhythm-control approach such as electrical cardioversion.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Nilotinib 的其他交互作用
Ibutilide 的其他交互作用
常見問題
Can I take Ibutilide with Nilotinib?
MediHelp rates the interaction as contraindicated. Ibutilide and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and has a high torsades risk. Adding nilotinib, which also prolongs QT, further increases the likelihood of life-threatening ventricular arrhythmia.
How serious is the interaction between Ibutilide and Nilotinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Consider another rhythm-control approach such as electrical cardioversion.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
