藥物交互作用
Insulin neutral human + Pioglitazone
嚴重程度: 嚴重
Insulin neutral human and Pioglitazone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Combining pioglitazone with insulin improves glycemic control but increases the risk of hypoglycemia, fluid retention, edema and heart failure. The risk of heart failure is higher in patients with existing cardiac disease.
用白話說明這項交互作用的意義
Insulin neutral human and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin neutral human belongs to Endocrine; Pioglitazone belongs to Endocrine.
為什麼會發生
Additive glucose lowering through improved insulin sensitivity, together with insulin- and PPAR-gamma-mediated renal sodium and fluid retention.
處置方式
Consider reducing the insulin dose when pioglitazone is added, and monitor glucose, weight and signs of edema or heart failure. Avoid in patients with symptomatic heart failure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Insulin neutral human 的其他交互作用
Pioglitazone 的其他交互作用
常見問題
Can I take Insulin neutral human with Pioglitazone?
MediHelp rates the interaction as major. Insulin neutral human and Pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining pioglitazone with insulin improves glycemic control but increases the risk of hypoglycemia, fluid retention, edema and heart failure. The risk of heart failure is higher in patients with existing cardiac disease.
How serious is the interaction between Insulin neutral human and Pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when pioglitazone is added, and monitor glucose, weight and signs of edema or heart failure. Avoid in patients with symptomatic heart failure.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
