藥物交互作用
Isosorbide mononitrate + Vardenafil
嚴重程度: 禁忌併用
Isosorbide mononitrate and Vardenafil: contraindicated interaction.
最後更新
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摘要
Vardenafil inhibits PDE5 and isosorbide mononitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
用白話說明這項交互作用的意義
Isosorbide mononitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
為什麼會發生
PDE5 inhibition potentiates nitrate-induced cGMP vasodilation
處置方式
Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Vardenafil 的其他交互作用
Isosorbide mononitrate 的其他交互作用
常見問題
Can I take Isosorbide mononitrate with Vardenafil?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil inhibits PDE5 and isosorbide mononitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.
How serious is the interaction between Isosorbide mononitrate and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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