藥物交互作用
Ergotamine + Isosorbide mononitrate
嚴重程度: 嚴重
Ergotamine and Isosorbide mononitrate: major interaction.
最後更新
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摘要
Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Ergot derivatives may also reduce the effect of nitrates, and the clinical effect is a loss of antianginal efficacy.
用白話說明這項交互作用的意義
Ergotamine and Isosorbide mononitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Isosorbide mononitrate belongs to Cardiovascular.
為什麼會發生
Pharmacodynamic antagonism between ergotamine vasoconstriction and nitrate vasodilation.
處置方式
Avoid in patients with coronary disease; choose a non-ergot migraine therapy that is safe in ischaemic heart disease where possible, and monitor for angina and blood pressure rise if unavoidable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Isosorbide mononitrate 的其他交互作用
Ergotamine 的其他交互作用
常見問題
Can I take Ergotamine with Isosorbide mononitrate?
MediHelp rates the interaction as major. Ergotamine and Isosorbide mononitrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine causes vasoconstriction and can provoke angina or raise blood pressure, opposing the antianginal action of nitrates. Ergot derivatives may also reduce the effect of nitrates, and the clinical effect is a loss of antianginal efficacy.
How serious is the interaction between Ergotamine and Isosorbide mononitrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with coronary disease; choose a non-ergot migraine therapy that is safe in ischaemic heart disease where possible, and monitor for angina and blood pressure rise if unavoidable.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
