藥物交互作用
Doravirine + Phenobarbitone
嚴重程度: 禁忌併用
Doravirine and Phenobarbitone: contraindicated interaction.
最後更新
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摘要
Phenobarbital is expected to lower doravirine exposure considerably, risking virologic failure and resistance. Labeling contraindicates strong CYP3A inducers with doravirine.
用白話說明這項交互作用的意義
Doravirine and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Phenobarbitone belongs to Central Nervous System.
為什麼會發生
Phenobarbital induces CYP3A4, accelerating doravirine metabolism.
處置方式
Avoid the combination and use an alternative anticonvulsant or antiretroviral regimen. Allow for the long duration of enzyme induction after stopping phenobarbital before starting doravirine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Doravirine 的其他交互作用
Phenobarbitone 的其他交互作用
常見問題
Can I take Doravirine with Phenobarbitone?
MediHelp rates the interaction as contraindicated. Doravirine and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbital is expected to lower doravirine exposure considerably, risking virologic failure and resistance. Labeling contraindicates strong CYP3A inducers with doravirine.
How serious is the interaction between Doravirine and Phenobarbitone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative anticonvulsant or antiretroviral regimen. Allow for the long duration of enzyme induction after stopping phenobarbital before starting doravirine.
What other medicines interact with Doravirine?
MediHelp also lists interactions of Doravirine with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Doravirine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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