藥物交互作用
Ketorolac intranasal + Vitamin k1
嚴重程度: 中度
Ketorolac intranasal and Vitamin k1: moderate interaction.
最後更新
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摘要
Ketorolac inhibits platelet function and increases bleeding risk, which may work against the aim of phytonadione in bleeding or coagulopathy. Systemic exposure from the nasal form is lower than oral or injected ketorolac but still present.
用白話說明這項交互作用的意義
Ketorolac intranasal and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Ketorolac's reversible COX-1 inhibition impairs platelet aggregation, a pharmacodynamic effect not corrected by vitamin K.
處置方式
Avoid ketorolac in patients with active bleeding or vitamin K-responsive coagulopathy; choose a non-NSAID analgesic.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Vitamin k1 的其他交互作用
常見問題
Can I take Ketorolac intranasal with Vitamin k1?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac inhibits platelet function and increases bleeding risk, which may work against the aim of phytonadione in bleeding or coagulopathy. Systemic exposure from the nasal form is lower than oral or injected ketorolac but still present.
How serious is the interaction between Ketorolac intranasal and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients with active bleeding or vitamin K-responsive coagulopathy; choose a non-NSAID analgesic.
What other medicines interact with Vitamin k1?
MediHelp also lists interactions of Vitamin k1 with, for example, Warfarin, Cholestyramine, Colestipol. The full list is on the Vitamin k1 page.
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