藥物交互作用
Vitamin k1 + Warfarin
嚴重程度: 嚴重
Vitamin k1 and Warfarin: major interaction.
最後更新
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摘要
Vitamin K1 directly antagonizes warfarin and reduces INR, leading to loss of anticoagulation. This is used therapeutically for reversal but can cause unintended resistance with supplements.
用白話說明這項交互作用的意義
Vitamin k1 and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vitamin k1 belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
為什麼會發生
Vitamin K1 restores synthesis of clotting factors II, VII, IX and X, opposing warfarin's inhibition of VKOR.
處置方式
Keep vitamin K intake consistent and monitor INR whenever dosing changes; when used for reversal, titrate dose to INR and bleeding status.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Warfarin 的其他交互作用
Vitamin k1 的其他交互作用
常見問題
Can I take Vitamin k1 with Warfarin?
MediHelp rates the interaction as major. Vitamin k1 and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin K1 directly antagonizes warfarin and reduces INR, leading to loss of anticoagulation. This is used therapeutically for reversal but can cause unintended resistance with supplements.
How serious is the interaction between Vitamin k1 and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep vitamin K intake consistent and monitor INR whenever dosing changes; when used for reversal, titrate dose to INR and bleeding status.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
