藥物交互作用
Levodopa + Phenelzine (nonselective MAOI)
嚴重程度: 禁忌併用
Levodopa and Phenelzine (nonselective MAOI): contraindicated interaction.
最後更新 來源: US FDA label
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摘要
Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.
用白話說明這項交互作用的意義
Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Nonselective MAO inhibition blocks breakdown of dopamine and norepinephrine formed from levodopa, causing excessive catecholamine accumulation and a pressor response.
處置方式
Do not combine. Stop phenelzine at least 14 days before starting levodopa.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
Levodopa 的其他交互作用
常見問題
Can I take Levodopa with Phenelzine (nonselective MAOI)?
MediHelp rates the interaction as contraindicated. Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.
How serious is the interaction between Levodopa and Phenelzine (nonselective MAOI)?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Stop phenelzine at least 14 days before starting levodopa.
What other medicines interact with Levodopa?
MediHelp also lists interactions of Levodopa with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Levodopa page.
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