藥物交互作用
Chlorpromazine + Levodopa
嚴重程度: 嚴重
Chlorpromazine and Levodopa: major interaction.
最後更新
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摘要
Chlorpromazine blocks dopamine D2 receptors and so opposes the effect of levodopa, which can worsen parkinsonian symptoms. Levodopa may also be less effective in controlling motor function.
用白話說明這項交互作用的意義
Chlorpromazine and Levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
為什麼會發生
Pharmacodynamic antagonism: D2 receptor blockade counteracts dopamine replacement.
處置方式
Avoid chlorpromazine in patients with Parkinson disease. If an antipsychotic is needed, use quetiapine or clozapine, or pimavanserin where appropriate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorpromazine 的其他交互作用
Levodopa 的其他交互作用
常見問題
Can I take Chlorpromazine with Levodopa?
MediHelp rates the interaction as major. Chlorpromazine and Levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine blocks dopamine D2 receptors and so opposes the effect of levodopa, which can worsen parkinsonian symptoms. Levodopa may also be less effective in controlling motor function.
How serious is the interaction between Chlorpromazine and Levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chlorpromazine in patients with Parkinson disease. If an antipsychotic is needed, use quetiapine or clozapine, or pimavanserin where appropriate.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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