藥物交互作用
Levodopa + Tranylcypromine
嚴重程度: 禁忌併用
Levodopa and Tranylcypromine: contraindicated interaction.
最後更新
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摘要
Levodopa is converted to dopamine and norepinephrine, and nonselective MAO inhibition prevents their breakdown. This can produce hypertensive crisis with severe headache and cardiovascular events.
用白話說明這項交互作用的意義
Levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levodopa belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
為什麼會發生
Increased catecholamine formation with blocked MAO-A and MAO-B degradation causes exaggerated pressor effects.
處置方式
Avoid the combination and stop the nonselective MAOI at least 14 days before starting levodopa. Selective MAO-B inhibitors are used in Parkinson disease under guidance.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tranylcypromine 的其他交互作用
Levodopa 的其他交互作用
常見問題
Can I take Levodopa with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and norepinephrine, and nonselective MAO inhibition prevents their breakdown. This can produce hypertensive crisis with severe headache and cardiovascular events.
How serious is the interaction between Levodopa and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 14 days before starting levodopa. Selective MAO-B inhibitors are used in Parkinson disease under guidance.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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