藥物交互作用
Levothyroxine + Raloxifene
嚴重程度: 中度
Levothyroxine and Raloxifene: moderate interaction.
最後更新
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摘要
Taking raloxifene together with oral levothyroxine can reduce levothyroxine absorption. This may raise TSH and cause symptoms of under-replacement in patients with hypothyroidism.
用白話說明這項交互作用的意義
Levothyroxine and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Raloxifene belongs to Endocrine.
為什麼會發生
Raloxifene may bind levothyroxine in the gut or otherwise impair its gastrointestinal absorption.
處置方式
Separate the two drugs by at least 4 hours. Check TSH about 6 to 8 weeks after starting or stopping raloxifene and adjust the levothyroxine dose as needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Raloxifene 的其他交互作用
Levothyroxine 的其他交互作用
常見問題
Can I take Levothyroxine with Raloxifene?
MediHelp rates the interaction as moderate. Levothyroxine and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking raloxifene together with oral levothyroxine can reduce levothyroxine absorption. This may raise TSH and cause symptoms of under-replacement in patients with hypothyroidism.
How serious is the interaction between Levothyroxine and Raloxifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the two drugs by at least 4 hours. Check TSH about 6 to 8 weeks after starting or stopping raloxifene and adjust the levothyroxine dose as needed.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Ospemifene, Apalutamide. The full list is on the Raloxifene page.
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