藥物交互作用
Ospemifene + Raloxifene
嚴重程度: 嚴重
Ospemifene and Raloxifene: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs are estrogen receptor modulators that act on the same receptors and carry similar risks, including venous thromboembolism. Taking them together adds no proven benefit and may increase thromboembolic risk and cause unpredictable receptor effects.
用白話說明這項交互作用的意義
Ospemifene and Raloxifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ospemifene belongs to Endocrine; Raloxifene belongs to Endocrine.
為什麼會發生
Duplicate selective estrogen receptor modulator activity with additive pharmacodynamic effects, including prothrombotic effects.
處置方式
Avoid using the two agents together and choose one based on the indication (osteoporosis versus dyspareunia). If switching, stop one before starting the other.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Raloxifene 的其他交互作用
Ospemifene 的其他交互作用
常見問題
Can I take Ospemifene with Raloxifene?
MediHelp rates the interaction as major. Ospemifene and Raloxifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are estrogen receptor modulators that act on the same receptors and carry similar risks, including venous thromboembolism. Taking them together adds no proven benefit and may increase thromboembolic risk and cause unpredictable receptor effects.
How serious is the interaction between Ospemifene and Raloxifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two agents together and choose one based on the indication (osteoporosis versus dyspareunia). If switching, stop one before starting the other.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Apalutamide, Levothyroxine. The full list is on the Raloxifene page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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