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Lonafarnib + Secobarbital

嚴重程度: 禁忌併用

Lonafarnib and Secobarbital: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by secobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.

用白話說明這項交互作用的意義

Lonafarnib and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lonafarnib belongs to Miscellaneous; Secobarbital belongs to Central Nervous System.

證據等級: Moderate

為什麼會發生

Barbiturate-mediated CYP3A4 induction increases lonafarnib metabolism.

處置方式

Avoid the combination. Select a non-inducing alternative to secobarbital.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Lonafarnib 與 Secobarbital 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Lonafarnib with Secobarbital?

MediHelp rates the interaction as contraindicated. Lonafarnib and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, so enzyme induction by secobarbital can greatly reduce its exposure. This could cause loss of efficacy. Labeling prohibits use with strong or moderate CYP3A inducers.

How serious is the interaction between Lonafarnib and Secobarbital?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Select a non-inducing alternative to secobarbital.

What other medicines interact with Secobarbital?

MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.

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