藥物交互作用
Lorlatinib + Secobarbital
嚴重程度: 禁忌併用
Lorlatinib and Secobarbital: contraindicated interaction.
最後更新
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摘要
Secobarbital, a barbiturate, induces CYP3A and may substantially lower lorlatinib exposure. Strong CYP3A inducers have caused hepatotoxicity with lorlatinib and may reduce its antitumor effect.
用白話說明這項交互作用的意義
Lorlatinib and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lorlatinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
為什麼會發生
Barbiturate induction of CYP3A increases lorlatinib clearance and reduces plasma concentrations.
處置方式
Do not co-administer; use a non-inducing sedative. If an inducer must be stopped, wait about three half-lives before starting lorlatinib.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Secobarbital 的其他交互作用
Lorlatinib 的其他交互作用
常見問題
Can I take Lorlatinib with Secobarbital?
MediHelp rates the interaction as contraindicated. Lorlatinib and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Secobarbital, a barbiturate, induces CYP3A and may substantially lower lorlatinib exposure. Strong CYP3A inducers have caused hepatotoxicity with lorlatinib and may reduce its antitumor effect.
How serious is the interaction between Lorlatinib and Secobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing sedative. If an inducer must be stopped, wait about three half-lives before starting lorlatinib.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
