藥物交互作用
Doravirine + Secobarbital
嚴重程度: 禁忌併用
Doravirine and Secobarbital: contraindicated interaction.
最後更新
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摘要
Barbiturates induce CYP3A4 and can substantially lower doravirine concentrations. This risks loss of virologic suppression and development of resistance. Doravirine labeling advises against strong CYP3A inducers.
用白話說明這項交互作用的意義
Doravirine and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doravirine belongs to Anti Virals; Secobarbital belongs to Central Nervous System.
為什麼會發生
Barbiturate-mediated CYP3A4 induction increases doravirine metabolism.
處置方式
Avoid the combination and use a non-inducing hypnotic or sedative. If an inducer is unavoidable, use an alternative antiretroviral regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Secobarbital 的其他交互作用
Doravirine 的其他交互作用
常見問題
Can I take Doravirine with Secobarbital?
MediHelp rates the interaction as contraindicated. Doravirine and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates induce CYP3A4 and can substantially lower doravirine concentrations. This risks loss of virologic suppression and development of resistance. Doravirine labeling advises against strong CYP3A inducers.
How serious is the interaction between Doravirine and Secobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing hypnotic or sedative. If an inducer is unavoidable, use an alternative antiretroviral regimen.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Elbasvir / grazoprevir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Secobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
