藥物交互作用
Mirtazapine + Phenelzine
嚴重程度: 禁忌併用
Mirtazapine and Phenelzine: contraindicated interaction.
最後更新
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摘要
Combining mirtazapine with a nonselective MAO inhibitor can cause serotonin syndrome, with hyperthermia, rigidity, myoclonus and autonomic instability. Mirtazapine labeling contraindicates use with MAOIs or within 14 days of stopping one.
用白話說明這項交互作用的意義
Mirtazapine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mirtazapine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
為什麼會發生
Irreversible MAO inhibition increases monoamine levels, which adds to the serotonergic and noradrenergic effects of mirtazapine.
處置方式
Do not coadminister. Wait at least 14 days after stopping phenelzine before starting mirtazapine, and at least 14 days after stopping mirtazapine before starting phenelzine.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Mirtazapine 的其他交互作用
Phenelzine 的其他交互作用
常見問題
Can I take Mirtazapine with Phenelzine?
MediHelp rates the interaction as contraindicated. Mirtazapine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining mirtazapine with a nonselective MAO inhibitor can cause serotonin syndrome, with hyperthermia, rigidity, myoclonus and autonomic instability. Mirtazapine labeling contraindicates use with MAOIs or within 14 days of stopping one.
How serious is the interaction between Mirtazapine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Wait at least 14 days after stopping phenelzine before starting mirtazapine, and at least 14 days after stopping mirtazapine before starting phenelzine.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Pimozide, Procarbazine. The full list is on the Mirtazapine page.
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