藥物交互作用
Mirtazapine + Rasagiline
嚴重程度: 禁忌併用
Mirtazapine and Rasagiline: contraindicated interaction.
最後更新
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摘要
Combining mirtazapine with the MAO-B inhibitor rasagiline raises the risk of serotonin syndrome and, at higher doses where selectivity is lost, of hypertensive reactions. Labeling advises against concurrent use and requires a washout between the drugs.
用白話說明這項交互作用的意義
Mirtazapine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mirtazapine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
為什麼會發生
Additive increase in synaptic serotonin and norepinephrine through MAO inhibition combined with mirtazapine's monoaminergic enhancement.
處置方式
Do not co-administer; wait at least 14 days after stopping rasagiline before starting mirtazapine, and at least 14 days after stopping mirtazapine before starting rasagiline.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Mirtazapine 的其他交互作用
Rasagiline 的其他交互作用
常見問題
Can I take Mirtazapine with Rasagiline?
MediHelp rates the interaction as contraindicated. Mirtazapine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining mirtazapine with the MAO-B inhibitor rasagiline raises the risk of serotonin syndrome and, at higher doses where selectivity is lost, of hypertensive reactions. Labeling advises against concurrent use and requires a washout between the drugs.
How serious is the interaction between Mirtazapine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; wait at least 14 days after stopping rasagiline before starting mirtazapine, and at least 14 days after stopping mirtazapine before starting rasagiline.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
