藥物交互作用
Ozanimod + Procarbazine
嚴重程度: 禁忌併用
Ozanimod and Procarbazine: contraindicated interaction.
最後更新
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摘要
Ozanimod's active metabolites are formed and cleared through pathways involving MAO-B, and the labeling advises against use with MAO inhibitors. Procarbazine's MAO inhibition could alter exposure to these metabolites and may raise the risk of a hypertensive reaction. Procarbazine also adds immunosuppression and myelosuppression to the effects of ozanimod.
用白話說明這項交互作用的意義
Ozanimod and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Procarbazine belongs to Oncology.
為什麼會發生
MAO inhibition may alter ozanimod metabolite exposure and increases the risk of a hypertensive reaction through added sympathomimetic effects.
處置方式
Do not use together. Allow at least 14 days between stopping either drug and starting the other.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Procarbazine 的其他交互作用
Ozanimod 的其他交互作用
常見問題
Can I take Ozanimod with Procarbazine?
MediHelp rates the interaction as contraindicated. Ozanimod and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed and cleared through pathways involving MAO-B, and the labeling advises against use with MAO inhibitors. Procarbazine's MAO inhibition could alter exposure to these metabolites and may raise the risk of a hypertensive reaction. Procarbazine also adds immunosuppression and myelosuppression to the effects of ozanimod.
How serious is the interaction between Ozanimod and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
