藥物交互作用
Ozanimod + Safinamide
嚴重程度: 禁忌併用
Ozanimod and Safinamide: contraindicated interaction.
最後更新
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摘要
Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
用白話說明這項交互作用的意義
Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
為什麼會發生
MAO-B inhibition alters formation of ozanimod's active metabolites, which may also inhibit MAO, creating a risk of excess adrenergic stimulation.
處置方式
Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Safinamide 的其他交互作用
Ozanimod 的其他交互作用
常見問題
Can I take Ozanimod with Safinamide?
MediHelp rates the interaction as contraindicated. Ozanimod and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed partly via MAO-B, and inhibition may change exposure and could allow nonselective MAO inhibition. Hypertensive crisis is a theoretical risk, and the clinical interaction has not been fully studied.
How serious is the interaction between Ozanimod and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as per ozanimod labeling. Allow at least 14 days between stopping one and starting the other.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
