藥物交互作用
Ozanimod + Tranylcypromine
嚴重程度: 禁忌併用
Ozanimod and Tranylcypromine: contraindicated interaction.
最後更新
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摘要
Ozanimod's metabolism involves MAO-B, and its active metabolites may inhibit MAO. Combination with MAO inhibitors could cause hypertensive crisis or altered ozanimod exposure. Labeling contraindicates concurrent use.
用白話說明這項交互作用的意義
Ozanimod and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ozanimod belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
為什麼會發生
MAO inhibition alters ozanimod metabolite formation, and the metabolites may add MAO inhibition, risking adrenergic excess.
處置方式
Do not co-administer. Allow at least 14 days between stopping either drug and starting the other, per labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Tranylcypromine 的其他交互作用
Ozanimod 的其他交互作用
常見問題
Can I take Ozanimod with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Ozanimod and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's metabolism involves MAO-B, and its active metabolites may inhibit MAO. Combination with MAO inhibitors could cause hypertensive crisis or altered ozanimod exposure. Labeling contraindicates concurrent use.
How serious is the interaction between Ozanimod and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other, per labeling.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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