藥物交互作用
Palovarotene + Tretinoin
嚴重程度: 嚴重
Palovarotene and Tretinoin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Palovarotene is an oral retinoid, and adding another systemic retinoid may lead to hypervitaminosis A-like toxicity. Effects include mucocutaneous dryness, headache, bone and liver toxicity.
用白話說明這項交互作用的意義
Palovarotene and Tretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palovarotene belongs to Miscellaneous; Tretinoin belongs to Dermatology.
為什麼會發生
Additive retinoid receptor activation and retinoid toxicity.
處置方式
Avoid concurrent systemic retinoids with palovarotene. If tretinoin is essential, monitor closely for retinoid toxicity and liver function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tretinoin 的其他交互作用
Palovarotene 的其他交互作用
常見問題
Can I take Palovarotene with Tretinoin?
MediHelp rates the interaction as major. Palovarotene and Tretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is an oral retinoid, and adding another systemic retinoid may lead to hypervitaminosis A-like toxicity. Effects include mucocutaneous dryness, headache, bone and liver toxicity.
How serious is the interaction between Palovarotene and Tretinoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic retinoids with palovarotene. If tretinoin is essential, monitor closely for retinoid toxicity and liver function.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
