藥物交互作用
Polymyxin b + Rocuronium
嚴重程度: 嚴重
Polymyxin b and Rocuronium: major interaction.
最後更新
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摘要
Polymyxin B has neuromuscular blocking properties and can intensify and prolong rocuronium paralysis. This can lead to prolonged respiratory muscle weakness or apnea, particularly with renal dysfunction.
用白話說明這項交互作用的意義
Polymyxin b and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Polymyxin b belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
為什麼會發生
Additive neuromuscular blockade through presynaptic inhibition of acetylcholine release and reduced postsynaptic sensitivity from polymyxin B.
處置方式
Avoid concurrent use where an alternative antibiotic is suitable; if needed, reduce rocuronium dose and monitor with train-of-four. Have ventilatory support ready; neostigmine reversal may be incomplete.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Rocuronium 的其他交互作用
Polymyxin b 的其他交互作用
常見問題
Can I take Polymyxin b with Rocuronium?
MediHelp rates the interaction as major. Polymyxin b and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B has neuromuscular blocking properties and can intensify and prolong rocuronium paralysis. This can lead to prolonged respiratory muscle weakness or apnea, particularly with renal dysfunction.
How serious is the interaction between Polymyxin b and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative antibiotic is suitable; if needed, reduce rocuronium dose and monitor with train-of-four. Have ventilatory support ready; neostigmine reversal may be incomplete.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
