藥物交互作用
Prednisone + Retifanlimab
嚴重程度: 中度
Prednisone and Retifanlimab: moderate interaction.
最後更新
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摘要
Systemic corticosteroids given before or at the start of PD-1 blockade may blunt the immune response and reduce efficacy. Corticosteroids remain appropriate for treating immune-related adverse reactions after starting retifanlimab.
用白話說明這項交互作用的意義
Prednisone and Retifanlimab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Retifanlimab belongs to Oncology.
為什麼會發生
Pharmacodynamic antagonism: corticosteroid immunosuppression counteracts T-cell activation by PD-1 blockade.
處置方式
Avoid starting immunosuppressive doses of prednisone before retifanlimab unless essential; physiological doses up to 10 mg/day are acceptable. Use corticosteroids as needed to manage immune-related reactions.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Retifanlimab 的其他交互作用
Prednisone 的其他交互作用
常見問題
Can I take Prednisone with Retifanlimab?
MediHelp rates the interaction as moderate. Prednisone and Retifanlimab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids given before or at the start of PD-1 blockade may blunt the immune response and reduce efficacy. Corticosteroids remain appropriate for treating immune-related adverse reactions after starting retifanlimab.
How serious is the interaction between Prednisone and Retifanlimab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting immunosuppressive doses of prednisone before retifanlimab unless essential; physiological doses up to 10 mg/day are acceptable. Use corticosteroids as needed to manage immune-related reactions.
What other medicines interact with Retifanlimab?
MediHelp also lists interactions of Retifanlimab with, for example, Piperacillin-tazobactam, Piperacillin, Penicillin g. The full list is on the Retifanlimab page.
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