Drug interactions
Upadacitinib + Vedolizumab
Severity: Major
Upadacitinib and Vedolizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a JAK inhibitor with another biologic immunosuppressant increases the risk of serious infection. Vedolizumab acts mainly in the gut, so systemic effects are smaller, but combination data are limited.
What this interaction means in plain words
Upadacitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Upadacitinib belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression via gut-selective integrin blockade and JAK inhibition.
What to do
Avoid routine concurrent use; the upadacitinib label advises against combination with biologic immunosuppressants. If combined, monitor closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Upadacitinib with Vedolizumab?
MediHelp rates the interaction as major. Upadacitinib and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using a JAK inhibitor with another biologic immunosuppressant increases the risk of serious infection. Vedolizumab acts mainly in the gut, so systemic effects are smaller, but combination data are limited.
How serious is the interaction between Upadacitinib and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; the upadacitinib label advises against combination with biologic immunosuppressants. If combined, monitor closely for infection.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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