Drug interactions
Edoxaban + Rivaroxaban
Severity: Major
Edoxaban and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are direct factor Xa inhibitors, so concurrent use duplicates anticoagulant activity and increases the risk of serious bleeding. Overlap should be limited to short transitions between agents.
What this interaction means in plain words
Edoxaban and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Duplicate direct factor Xa inhibition causing additive anticoagulation.
What to do
Avoid long-term combined use and give only one agent. During switching, start the new drug when the next dose of the other is due and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Rivaroxaban?
MediHelp rates the interaction as major. Edoxaban and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are direct factor Xa inhibitors, so concurrent use duplicates anticoagulant activity and increases the risk of serious bleeding. Overlap should be limited to short transitions between agents.
How serious is the interaction between Edoxaban and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combined use and give only one agent. During switching, start the new drug when the next dose of the other is due and monitor for bleeding.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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