Drug interactions
Ambrisentan + Fluconazole
Severity: Minor
Ambrisentan and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may modestly increase ambrisentan exposure because ambrisentan is partly metabolized by CYP3A4 and CYP2C19. The clinical effect is usually small, but adverse effects such as edema, headache and anemia could increase.
What this interaction means in plain words
Ambrisentan and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibition of CYP2C19 and CYP3A4 reduces ambrisentan clearance.
What to do
No routine dose change is needed. Monitor for edema, hypotension and hemoglobin decline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Fluconazole?
MediHelp rates the interaction as minor. Ambrisentan and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may modestly increase ambrisentan exposure because ambrisentan is partly metabolized by CYP3A4 and CYP2C19. The clinical effect is usually small, but adverse effects such as edema, headache and anemia could increase.
How serious is the interaction between Ambrisentan and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for edema, hypotension and hemoglobin decline.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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