Drug interactions
Ambrisentan + Itraconazole
Severity: Minor
Ambrisentan and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 and P-gp inhibitor and may modestly raise ambrisentan exposure, since ambrisentan is partly metabolised by CYP3A4. Studies with strong CYP3A4 inhibitors showed no clinically important change, so any effect is small.
What this interaction means in plain words
Ambrisentan and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, slightly reducing ambrisentan clearance.
What to do
No routine dose change is needed; monitor for ambrisentan adverse effects such as edema, headache and anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Itraconazole?
MediHelp rates the interaction as minor. Ambrisentan and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole is a strong CYP3A4 and P-gp inhibitor and may modestly raise ambrisentan exposure, since ambrisentan is partly metabolised by CYP3A4. Studies with strong CYP3A4 inhibitors showed no clinically important change, so any effect is small.
How serious is the interaction between Ambrisentan and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for ambrisentan adverse effects such as edema, headache and anemia.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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