Drug interactions
Ambrisentan + Omeprazole
Severity: Minor
Ambrisentan and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ambrisentan is partly metabolized by CYP2C19, and omeprazole could slightly raise its levels. Studies of CYP2C19 inhibition showed no clinically important change in ambrisentan exposure.
What this interaction means in plain words
Ambrisentan and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition by omeprazole may modestly reduce ambrisentan metabolism.
What to do
No dose adjustment is needed; monitor for ambrisentan adverse effects such as edema and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Omeprazole?
MediHelp rates the interaction as minor. Ambrisentan and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ambrisentan is partly metabolized by CYP2C19, and omeprazole could slightly raise its levels. Studies of CYP2C19 inhibition showed no clinically important change in ambrisentan exposure.
How serious is the interaction between Ambrisentan and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for ambrisentan adverse effects such as edema and headache.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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