Drug interactions
Aminolevulinic acid + Naproxen
Severity: Moderate
Aminolevulinic acid and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminolevulinic acid causes protoporphyrin IX accumulation and skin photosensitivity. Naproxen is itself a recognised photosensitising drug, so the combination may increase the risk of phototoxic skin reactions after sun or bright light exposure.
What this interaction means in plain words
Aminolevulinic acid and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Naproxen belongs to Musculoskeletal.
Why it happens
Additive phototoxic effects from two photosensitising agents.
What to do
Avoid giving naproxen and other photosensitisers around the perioperative period of aminolevulinic acid dosing, and use an alternative analgesic if possible. Counsel the patient to protect skin and eyes from light during the photosensitivity period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Naproxen?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid causes protoporphyrin IX accumulation and skin photosensitivity. Naproxen is itself a recognised photosensitising drug, so the combination may increase the risk of phototoxic skin reactions after sun or bright light exposure.
How serious is the interaction between Aminolevulinic acid and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving naproxen and other photosensitisers around the perioperative period of aminolevulinic acid dosing, and use an alternative analgesic if possible. Counsel the patient to protect skin and eyes from light during the photosensitivity period.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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