Drug interactions
Aminolevulinic acid + Tolmetin
Severity: Moderate
Aminolevulinic acid and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral aminolevulinic acid increases protoporphyrin-related photosensitivity, and additional phototoxic drugs may increase skin reactions. NSAIDs can occasionally cause photosensitivity. The concern is mostly theoretical and limited to the perioperative period.
What this interaction means in plain words
Aminolevulinic acid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aminolevulinic acid belongs to Miscellaneous; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive phototoxic potential from drugs that sensitize the skin to light.
What to do
Avoid giving other potentially phototoxic drugs for 24 hours after oral aminolevulinic acid where alternatives exist. Counsel the patient to protect skin and eyes from light exposure during that time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Aminolevulinic acid
- Acitretin + Aminolevulinic acid Major
- Aminolevulinic acid + Doxycycline Major
- Aminolevulinic acid + Isotretinoin Major
- Aminolevulinic acid + Amiodarone Moderate
- Aminolevulinic acid + Amlodipine-hydrochlorothiazide-valsartan Moderate
- Aminolevulinic acid + Amlodipine-olmesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Aminolevulinic acid with Tolmetin?
MediHelp rates the interaction as moderate. Aminolevulinic acid and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid increases protoporphyrin-related photosensitivity, and additional phototoxic drugs may increase skin reactions. NSAIDs can occasionally cause photosensitivity. The concern is mostly theoretical and limited to the perioperative period.
How serious is the interaction between Aminolevulinic acid and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving other potentially phototoxic drugs for 24 hours after oral aminolevulinic acid where alternatives exist. Counsel the patient to protect skin and eyes from light exposure during that time.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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