Drug interactions
Amiodarone + Aprepitant
Severity: Moderate
Amiodarone and Aprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is metabolized in part by CYP3A4, so aprepitant may raise amiodarone concentrations. Higher exposure could increase the risk of bradycardia, QT prolongation and arrhythmia, although the clinical effect with short aprepitant courses is not well characterized.
What this interaction means in plain words
Amiodarone and Aprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing amiodarone metabolism.
What to do
Monitor heart rate and ECG, including QTc, during aprepitant therapy. Check electrolytes and review other QT-prolonging drugs, such as some antiemetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Aprepitant?
MediHelp rates the interaction as moderate. Amiodarone and Aprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone is metabolized in part by CYP3A4, so aprepitant may raise amiodarone concentrations. Higher exposure could increase the risk of bradycardia, QT prolongation and arrhythmia, although the clinical effect with short aprepitant courses is not well characterized.
How serious is the interaction between Amiodarone and Aprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, including QTc, during aprepitant therapy. Check electrolytes and review other QT-prolonging drugs, such as some antiemetics.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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