Drug interactions
Amiodarone + Armodafinil
Severity: Minor
Amiodarone and Armodafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly reduce amiodarone concentrations. The clinical relevance is probably small but loss of efficacy is possible.
What this interaction means in plain words
Amiodarone and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Armodafinil belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increasing amiodarone metabolism.
What to do
Monitor for recurrence of arrhythmia and consider ECG follow-up when armodafinil is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Amiodarone with Armodafinil?
MediHelp rates the interaction as minor. Amiodarone and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly reduce amiodarone concentrations. The clinical relevance is probably small but loss of efficacy is possible.
How serious is the interaction between Amiodarone and Armodafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of arrhythmia and consider ECG follow-up when armodafinil is started or stopped.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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