Drug interactions
Avatrombopag + Carbamazepine
Severity: Moderate
Avatrombopag and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce avatrombopag exposure and may cause inadequate platelet response. Labeling advises adjusting the starting dose in ITP when combined with such inducers.
What this interaction means in plain words
Avatrombopag and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C9, increasing avatrombopag metabolism.
What to do
Follow labeled dose adjustment for dual inducers and monitor platelet counts, adjusting the dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
- Avatrombopag + Ketoconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Carbamazepine?
MediHelp rates the interaction as moderate. Avatrombopag and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can reduce avatrombopag exposure and may cause inadequate platelet response. Labeling advises adjusting the starting dose in ITP when combined with such inducers.
How serious is the interaction between Avatrombopag and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow labeled dose adjustment for dual inducers and monitor platelet counts, adjusting the dose to response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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