Drug interactions
Avatrombopag + Bosentan
Severity: Moderate
Avatrombopag and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce avatrombopag exposure through CYP3A4 and possibly CYP2C9 induction, potentially diminishing the platelet response.
What this interaction means in plain words
Avatrombopag and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4 (and CYP2C9), accelerating avatrombopag clearance.
What to do
Monitor platelet counts and increase avatrombopag dose as recommended in labeling when used with inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
- Avatrombopag + Ketoconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Bosentan?
MediHelp rates the interaction as moderate. Avatrombopag and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce avatrombopag exposure through CYP3A4 and possibly CYP2C9 induction, potentially diminishing the platelet response.
How serious is the interaction between Avatrombopag and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and increase avatrombopag dose as recommended in labeling when used with inducers.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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